Application for an elective course

EXPERIMENTAL PHARAMCOLOGY AND PATHOLOGY

Course coordinators

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Professor Predrag Sikirić, MD, PhD
Department of Pharmacology
University of Zagreb, School of Medicine
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Professor Sven Seiwerth, MD, PhD
Department of Pathology
University of Zagreb, School of Medicine

Associate Course Coordinator

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Associate professor Alenka Boban Blagaić, DVM, PhD
Department of Pharmacology
University of Zagreb, School of Medicine

GENERAL CONTENT OF THE COURSE

The proposed course, Experimental Pharmacology and Pathology, aims to synthesize the existing theoretical knowledge from those courses and link it to the scientific approach in the development of new drugs, possible new therapeutic approaches, and their application in the industrial sector.

COURSE AIMS

COURSE DESCRIPTION

Pharmacology and Pathology are compulsory courses at several biomedical integrated undergraduate and graduate studies at the University of Zagreb. They are performed at the School of Medicine (the 6th semester of the Croatian and English studies), Faculty of Veterinary Medicine (the 5th and 6th semesters of the Croatian and English studies), School of Dental Medicine (the 5th and 6th semesters of the Croatian and English studies) and Faculty of Pharmacy and Biochemistry (the 7th semester of the Croatian studies of Pharmacy and Medical Biochemistry). Pathology is an exception for the Faculty of Pharmacy and Biochemistry – instead of the Pathology course, students of Pharmacy and Medical Biochemistry have the Pathophysiology with Pathology course.

The goal of pharmacology education is to teach students basic concepts of drugs. Students acquire knowledge of different molecular mechanisms of drug action, possible adverse and harmful effects as well as interactions of drugs. Pathology, on the other hand, aims to show students the mechanism of disease onset and their etiologies, pathogenesis, common morphological and biological features as well as pathological processes related to organ systems.

Although these courses have the same name and same description, they differ depending at which Faculty they are running. Because of this, the students of biomedical faculties base their knowledge, scientific questions, reflections and research through perspective of their home Faculty, which ultimately limits their scientific breadth. Therefore, the proposed course would provide a multidisciplinary approach to teaching, combining different perspectives arising from medical, veterinary, dentistry and pharmacy backgrounds. Students would be taught how to design and implement experiments, analyze the results, and publish their work. The proposed course will be held at the University of Zagreb School of Medicine and will be accessible to all interested students of the University of Zagreb biomedical faculties. The lecturers will be local and foreign teachers from biomedical faculties. The classes will be in English as a mixed form of teaching (lectures, seminars and exercises, e-learning). The e-learning will be performed by the existing LMS system (School of Medicine). Altogether, this would lead to increased mobility and better scientific cooperation between local and international students and teachers.

 

For students of

School of Medicine (3rd year students)

Faculty of Veterinary Medicine (3rd year students)

School of Dental Medicine (3rd year students) and

Faculty of Pharmacy and Biochemistry (4th year students)

of the University of Zagreb.

COURSE STRUCTURE

  • L1 – Introduction and history of experimental pharmacology and pathology (1h)
  • L2 – The role of laboratory animals in biomedical research (1h)
  • L3 – Biostatistics: types of data and statistical approach (1h)
  • L4 – Pentadecapeptide BPC 157 and concept of citoprotection (experimental models on GI tract) (2h)
  • eL1 – Electrophysiology of the heart (1h)

.

  • S1 – Spermatology – new model for pharmacology assessment (1h)
  • S2 – Study of composition and effects of agents for oral mucosa (1h)
  • S3 – Experimental models of liver diseases (1h)
  • S4 – Behavioral models of anxiety (1h)
  • S5 – Health monitoring –Laboratory animals (1h)
  • S6 – Most common statistical mistakes (1h)
  • S7 – Other organ systems involved in biologic stress (1h)
  • S8 – Experimental models of the female gender system (1h)
  • S9 – Effects of pentadecapeptide bpc 157 in models of cardiotoxicity (1h)
  • S10 – Pentadecapeptide BPC 157 and NSAID-s (1h)
  • S11 – Pain mechanisms and the metabotropic glutamate receptors (Block 1) (2h)
  • S11 – Brain-gut axis, stress-related gastrointestinal mucosal lesions (Block 1) (2h)
  • S12 – Mesenchymal stem cells of dental origin: high potential for treating hard   tissue, gastrointestinal and neural disorders (Block 2) (2h)
  • S12 – Immunosuppressants, helminths and microbiota transplantation – conventional and novel approaches to treat inflammatory bowel diseases (Block 2) (2h)
  • P1 – Practical work on silicone rat models (1h)
  • P2 – Computer-assisted tracking and analysis of behavioral dana (1h)
  • P3 – Experimental pathology (molecular pathology, cell and tissue culture) (2h)
  • eP1 – Experimental design

PLAN OF THE COURSE AND COURSE SCHEDULE

Introduction and history of experimental pharmacology

and pathology

(Sikirić – 2h L1)

Zoom

16.15h – 17.45h

The role of laboratory animals in biomedical research

(Boban Blagaić – 1h L2)

LMS – BBB Lecture room

17.55h – 18.40h

Spermatology – new model for pharmacology assessment

 (Matković – 1h S1)

Zoom

18.50h – 19.35h

Behavioral models of anxiety

(Tvrdeić – 1h S4)

LMS – BBB Lecture room

19.45h – 20.30h


Computer-assisted tracking and analysis of behavioral data

(Tvrdeić – 1h P2)

Practical room – Department for pharmacology

Group 1

16.15h – 16.45h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 2

16.15h – 16.45h


Computer-assisted tracking and analysis of behavioral data

(Tvrdeić – 1h P2)

Practical room – Department for pharmacology

Group 2

17.00h – 17.30h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 1

17.00h – 17.30h


Computer-assisted tracking and analysis of behavioral data

Practical room – Department for pharmacology

Group 3

17.45.-18.15h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 4

17.45h – 18.15h


Computer-assisted tracking and analysis of behavioral data

 (Tvrdeić – 1h P2)

Practical room – Department for pharmacology

Group 4

18.30h – 19.00h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 3

18.30h – 19.00h


Computer-assisted tracking and analysis of behavioral data

(Tvrdeić – 1h P2)

Practical room – Department for pharmacology

Group 5

19.15-19.45h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 6

19.15.-19.45h


Computer-assisted tracking and analysis of behavioral data

(Tvrdeić – 1h P2)

Practical room – Department for pharmacology

Group 6

20.00-20.30h


Practical work on silicone rat models

(Boban Blagaić – 1h P1)

Library – Croatian Institute for Brain Research

Group 5

20.00.-20.30h

Statistical concepts of scientific research

(Hackenberger K.-  1h L3)

Zoom

17.00h – 17.45h

Frequentistic and probabilistic approach to experimental design

(Hackenberger K.-  1h S6)

Zoom

17.55h – 18.40h

Health monitoring – laboratory animals

(Gudan Kurilj –  1h S5)

Zoom

18.50h – 19.35h

Study of composition and effects of agents for oral mucosa

(Alajbeg – 1h S2)

Zoom

19.45h – 20.30h

Other organ systems involved in biologic stress

 (Seiwerth– 1h S7)

LMS – BBB Lecture room

17.00h – 17.45h

Experimental models of the female reproductive system

(Batelja – 1h S8)

LMS – BBB Lecture room

17.55h – 18.40h

Experimental pathology

(molecular pathology, cell and tissue culture)

 (Šepac – 1h P3)

LMS – BBB Lecture room

18.50h – 19.35h

Experimental models of liver diseases

(Turčić – 1h S3)

Zoom

19.45h – 20.30h

Electrophysiology of the heart

(Žižak – 1h eL1)

LMS – BBB Lecture room

16.05-16.50

Effects of pentadecapeptide BPC 157 in models of cardiotoxicity

(Lovrić-Benčić – 1h S9)

Zoom

17.00h – 17.45h

New drugs: from idea to realisation

Pentadecapeptide BPC 157 and concept of citoprotection

(experimental models on GI tract)

 (Sikirić – 2h L4)

       Zoom

     17.55h – 19.35h


Pentadecapeptide BPC 157 and NSAIDs

 (Milković Periša – 1h S10)

Zoom

19.35h – 20.20h

Brain-gut axis, stress-related gastrointestinal mucosal lesions

(Gyresh – 2h S11)

17.00h – 18.30h

Immunosuppressants, helminths and microbiota transplantation – conventional and novel approaches to treat inflammatory bowel diseases

      (Zadory – 2h S12)

18.40h – 20.10h

Due to COVID – 19 pandemic all lectures and seminars will be taken online (Zoom or LMS – BBB platform)

Practicals on Day 2 will take place in: Practical room (Department of Pharmacology) and Library (Croatian Institute for Brain Research

 

Students will be notified in advance for any change regarding epidemiological situation.

EXAMINATION

Final Test (50 multiple choice questions).

Quiz score:

LIST OF LECTURERS (Alphabetically)

  • Professor Ivan Alajbeg, DMD, PhD, Department of Oral Medicine, University of Zagreb, School of Dental Medicine
  • Assistant professor Lovorka Batelja Vuletić, MD, PhD, Department of Pathology, University of Zagreb, School of Medicine
  • Associate professor Alenka Boban Blagaić, DVM, PhD, Department of Pharmacology, University of Zagreb, School of Medicine
  • Tihana Džombeta Regović, MD, PhD, Department of Pathology, University of Zagreb, School of Medicine
  • Professor  Željko Grabarević, DVM, PhD, Department of Veterinary Pathology, University of Zagreb, Faculty of Veterinary Medicine
  • Professor Martina Lovrić Benčić, MD, PhD, Department of Internal Medicine, University of Zagreb, School of Medicine
  • Assistant professor Marija Milković Periša, MD, PhD, Department of Pathology, University of Zagreb, School of Medicine
  • Associate professor Daria Pašalić, MSc Medical Biochemistry, PhD, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine
  • Professor Sven Seiwerth, MD, PhD, Department of Pathology, University of Zagreb, School of Medicine
  • Professor Predrag Sikirić, MD, PhD, Department of Pharmacology, University of Zagreb, School of Medicine
  • Assistant professor Petra Turčić, MPharm, PhD, Department of Pharmacology, University of Zagreb, Faculty of Pharmacy and Biochemistry,
  • Associate professor Ante Tvrdeić, MD, PhD, Department of Pharmacology, University of Zagreb, School of Medicine
  • Associate professor Mirza Žižak, MD, PhD, Department of Physiology, University of Zagreb, School of Medicine
  • Associate Professor  Andrea Gudan Kurilj, DVM, PhD, Department of Veterinary Pathology, University of Zagreb, Faculty of Veterinary Medicine
  • Ana Šepac MD, PhD, Department of Pathology, University of Zagreb, School of Medicine

EXTERNAL ASSOCIATES

  • Professor Gábor Gerber, DDS, PhD, Dean of Dental School Semmelweis University, Budapest, Hungary
  • Professor Klara Gyires, MD, PhD, Department of Pharmacology and Pharmacotherapy Semmelweis University, Faculty of Medicine, Budapest, Hungary
  • Mario Matković, MSc Biol, PhD, Veterinary ambulance “Simentalac”, Kutjevo
  • Associate professor Branimir Hackenberger Kutuzović, PhD, Department of Biology, University of Osijek, Head of Subdepartment for Quantitative Ecology

  • Professor Gábor Varga, DDS, PhD, Professor and Chair Department of Oral Biology Semmelweis University, Budapest, Hungary

  • Associate professor Zoltán Zádori, MD, PhD, Department of Pharmacology and Pharmacotherapy Semmelweis University, Faculty of Medicine, Budapest, Hungary

Our course will provide: